A tradução de manuais de instruções: relatório de estágio na AP | Portugal

O presente relatório de estágio realizado no âmbito do Mestrado em Tradução Especializada, na Universidade de Aveiro, apresenta o trabalho levado a cabo durante o estágio curricular com a duração de seis meses na empresa de tradução AP | Portugal. Este relatório encontra-se dividido por partes, uma parte inicial em que se procura dar a conhecer a empresa, incluindo a sua estrutura, a metodologia e as ferramentas de trabalho que fazem parte do processo de tradução. Numa segunda parte é apresentada uma análise aos projetos realizados durante o período de estágio na empresa. De seguida é feito um enquadramento teórico no âmbito da tradução especializada e por conseguinte uma análise mais aprofundada daquele que é o domínio da tradução técnica, do principal interveniente no mesmo, o tradutor técnico e finalmente são apresentadas as caraterísticas do texto técnico. Ainda nesta parte é objeto de estudo o género textual em análise neste relatório, o manual de instruções, aqui serão apresentados os problemas, dificuldades e desafios que podem ser encontrados durante a tradução deste tipo de material, que serão fundamentados com exemplos práticos, nomeadamente alguns dos trabalhos levados a cabo durante o estágio curricular. Numa parte mais final é elaborada uma análise e reflexão de todo o trabalho realizado, e também de todos os conhecimentos adquiridos tanto a nível das tecnologias de tradução como a nível do domínio técnico e da tradução de manuais de instruções.This report carried out as part of the master’s degree in Specialized Translation at the University of Aveiro, presents the work carried out during the six-month curricular internship at the translation company AP | Portugal. This report is divided into parts: an initial part in which the aim is to get to know the company, including its structure, methodology, and the work tools involved in the translation process. The second part presents an analysis of the projects carried out during the internship period in the company. Afterwards, a theoretical framework is provided in the field of specialized translation, followed by a more in-depth analysis of the field of technical translation, with a special emphasis on the technical translator, and finally an examination of the characteristics of the technical text. The textual genre under analysis in this report, the user manual, is also analyzed in this part, with an insight into the problems, difficulties and challenges that can be found during the translation of this type of material, which will be supported by practical examples, namely some of the work carried out during the curricular internship. In a final part, an analysis and reflection of all the work done is carried, as well as an overview of all the knowledge acquired both in terms of translation technologies but also at the level of the technical domain, including the translation of instruction manuals.Mestrado em Tradução Especializad

Bullying’s Negative Effect on Academic Achievement

Bullying's a phenomenon that carries great harm for those involved (bully or victim alike) in which academic achievement is harmed as well. However, the strength of such impact is yet to be clarified, existing many possibilities to explore. Or in other words, many variables that can justify such connection - classroom behavior being one example.The goal of the present investigation is to study the impact that bullying (while mediated by the classroom behavior) has on the academic achievement.The sample consisted of 288 children (from 1st year to 4th year’s students); and their teachers (whom reported their classroom behavior). Results showed that the bullying situation itself, didn’t significantly explain the academic achievement of those involved. However, from classroom behavior it was found an indirect effect between bullying and academic achievement. Within classroom behavior, the main contributive dimensions were - victim related, the excessive motor activity; and bully related, oppositional behaviors, excessive motor activity and ADHD index.This results alert to the importance of the educational agents’ attention given to the existing behavior in their classrooms. Not only because of the disruption created in each classroom’s environment, but also as a possible sign of an involvement in the existing bullying dynamics

Bullying’s negative effect on academic achievement

Bullying carries great harm for all involved, undermining academic achievement as well. The strength of such impact is yet to be clarified, existing many possibilities and variables to analyze – classroom behavior being one. The present cross-sectional investigation goal was to study the impact of bullying (mediated by the classroom behavior) on the academic achievement. Participants consisted of 288 children (from the 1st to 4th school years), 51% females and 49% males, and an average age of: M= 8.09 years (SD = 1.193; Min = 7.94, Max = 8.21). Children filled out a self-report questionnaire on bullying; their teachers reported on classroom behaviors and academic achievement. Results showed that the bullying situation itself, didn’t significantly explain the academic achievement of those involved. Indirect effects were found for both victims and perpetrators. Victims revealed worse school results through worse classroom behavior (specifically, excessive motor activity). Aggressor presented worse school results through worse classroom behavior (specifically, opposition behavior, excessive motor activity, and hyperactivity). These results highlight the importance of the educational agents’ attention to the existing behaviors in their classrooms, not only to the disruption established in each classroom’s environment, but as a possible sign of an involvement in the existing bullying dynamics.info:eu-repo/semantics/publishedVersio

Unexpected short- and long-term effects of chronic adolescent HU-210 exposure on emotional behavior

© 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by- nc-nd/4.0/).Chronic adolescent cannabinoid receptor agonist exposure has been shown to lead to persistent increases in depressive-like behaviors. This has been a key obstacle to the development of cannabinoid-based therapeutics. However, most of the published work has been performed with only three compounds, namely Δ9-tetrahydrocannabinol, CP55,940 and WIN55,212-2. Hypothesizing that different compounds may lead to distinct outcomes, we herein used the highly potent CB1R/CB2R full agonist HU-210, and first aimed at replicating cannabinoid-induced long-lasting effects, by exposing adolescent female Sprague-Dawley rats to increasing doses of HU-210, for 11 days and testing them at adulthood, after a 30-day drug washout. Surprisingly, HU-210 did not significantly impact adult anxious- or depressive-like behaviors. We then tested whether chronic adolescent HU-210 treatment resulted in short-term (24h) alterations in depressive-like behavior. Remarkably, HU-210 treatment simultaneously induced marked antidepressant- and prodepressant-like responses, in the modified forced swim (mFST) and sucrose preference tests (SPT), respectively. Hypothesizing that mFST results were a misleading artifact of HU-210-induced behavioral hyperreactivity to stress, we assessed plasmatic noradrenaline and corticosterone levels, under basal conditions and following an acute swim-stress episode. Notably, we found that while HU-210 did not alter basal noradrenaline or corticosterone levels, it greatly augmented the stress-induced increase in both. Our results show that, contrary to previously studied cannabinoid receptor agonists, HU-210 does not induce persisting depressive-like alterations, despite inducing marked short-term increases in stress-induced reactivity. By showing that not all cannabinoid receptor agonists may induce long-term negative effects, these results hold significant relevance for the development of cannabinoid-based therapeutics.Work was supported by project funding from Fundação para a Ciência e para a Tecnologia (FCT) (PTDC/MED-FAR/30933/2017 and PTDC/MED-FAR/4834/2021) and by H2020-WIDESPREAD-05-2017-Twinning (EpiEpinet) under grant agreement No. 952455. MF-F (SFRH/BD/147505/2019), NR (PD/BD/113463/2015), JF-G (PD/BD/114441/2016) and CM-L (SFRH/BD/118238/2016) are supported by PhD fellowships from FCT. The funding sources had no involvement in study design, preparation of the manuscript, or decision regarding its submission.info:eu-repo/semantics/publishedVersio

Utilização de dados do satélite Sentinel-2e de espectroscopia NIR para a quantificação de nutrientes na nogueira-comum (Juglans regia L.)

A determinação do teor de nutrientes em culturas agrícolas requer periodicidade na colheita de amostras foliares que serão futuramente analisadas em laboratórios acreditados para o efeito. Desta forma, são disponibilizadas aos agricultores recomendações de fertilização baseadas nos resultados das análises foliares. Este processo é moroso e requer uma recolha representativa das amostras principalmente em parcelas com um certo nível de heterogeneidade espacial. A existência de metodologias alternativas que permitam obter a informação acerca do teor de nutrientes em culturas agrícolas de forma rápida e mais representativas da parcela, será́ uma mais-valia importante na gestão da nutrição em qualquer espécie vegetal. Este trabalho teve como objetivo encontrar metodologias para avaliar o nível nutricional (teor de azoto (N), cálcio (Ca) e potássio (K)) de um pomar de nogueiras, recorrendo a informações do satélite de observação da Terra, Sentinel-2. Este trabalho decorreu durante a campanha de 2021 num pomar de nogueiras no Alentejo. Foram recolhidas amostras foliares em 6 datas diferentes e determinados, pelos métodos analíticos de referência, os teores de nutrientes de azoto cálcio e potássio, tendo os valores obtidos sido comparados com a informação das bandas espectrais disponibilizados pelo satélite Sentinel-2 e dos índices calculados: índice de vegetação por diferença normalizada (NDVI) e índice de água por diferença normalizada (NDWI). Foi utilizada a regressão linear múltipla para a obtenção de modelos de predição das variáveis resposta (teor de N, Ca e K) a partir das variáveis independentes. Os modelos obtidos para os nutrientes em estudo apresentaram um nível de confiança muito aceitável sendo considerados modelos relativamente robustos, tendo sido utilizados para a construção de mapas de distribuição espacial do N, Ca e K na cultura

Parenteral adjuvant effects of an enterotoxigenic Escherichia coli natural heat-labile toxin variant

Native type I heat-labile toxins (LTs) produced by enterotoxigenic Escherichia coli (ETEC) strains exert strong adjuvant effects on both antibody and T cell responses to soluble and particulate antigens following co-administration via mucosal routes. However, inherent enterotoxicity and neurotoxicity (following intra-nasal delivery) had reduced the interest in the use of these toxins as mucosal adjuvants. LTs can also behave as powerful and safe adjuvants following delivery via parenteral routes, particularly for activation of cytotoxic lymphocytes. In the present study, we evaluated the adjuvant effects of a new natural LT polymorphic form (LT2), after delivery via intradermal (i.d.) and subcutaneous (s.c.) routes, with regard to both antibody and T cell responses. A recombinant HIV-1 p24 protein was employed as a model antigen for determination of antigen-specific immune responses while the reference LT (LT1), produced by the ETEC H10407 strain, and a non-toxigenic LT form (LTK63) were employed as previously characterized LT types. LT-treated mice submitted to a four dose-base immunization regimen elicited similar p24-specific serum IgG responses and CD4(+) T cell activation. Nonetheless, mice immunized with LT1 or LT2 induced higher numbers of antigen-specific CD8(+) T cells and in vivo cytotoxic responses compared to mice immunized with the non-toxic LT derivative. These effects were correlated with stronger activation of local dendritic cell populations. In addition, mice immunized with LT1 and LT2, but not with LTK63, via s.c. or i.d. routes developed local inflammatory reactions. Altogether, the present results confirmed that the two most prevalent natural polymorphic LT variants (LT1 or LT2) display similar and strong adjuvant effects for subunit vaccines administered via i.d. or s.c. routes.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)National Institute of Science and Technology in Vaccines (INCTV

Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015

SummaryBackground The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease. By providing national and subnational assessments spanning the past 25 years, this study can inform debates on the importance of addressing risks in context. Methods We used the comparative risk assessment framework developed for previous iterations of the Global Burden of Disease Study to estimate attributable deaths, disability-adjusted life-years (DALYs), and trends in exposure by age group, sex, year, and geography for 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks from 1990 to 2015. This study included 388 risk-outcome pairs that met World Cancer Research Fund-defined criteria for convincing or probable evidence. We extracted relative risk and exposure estimates from randomised controlled trials, cohorts, pooled cohorts, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. We developed a metric that allows comparisons of exposure across risk factors—the summary exposure value. Using the counterfactual scenario of theoretical minimum risk level, we estimated the portion of deaths and DALYs that could be attributed to a given risk. We decomposed trends in attributable burden into contributions from population growth, population age structure, risk exposure, and risk-deleted cause-specific DALY rates. We characterised risk exposure in relation to a Socio-demographic Index (SDI). Findings Between 1990 and 2015, global exposure to unsafe sanitation, household air pollution, childhood underweight, childhood stunting, and smoking each decreased by more than 25%. Global exposure for several occupational risks, high body-mass index (BMI), and drug use increased by more than 25% over the same period. All risks jointly evaluated in 2015 accounted for 57·8% (95% CI 56·6–58·8) of global deaths and 41·2% (39·8–42·8) of DALYs. In 2015, the ten largest contributors to global DALYs among Level 3 risks were high systolic blood pressure (211·8 million [192·7 million to 231·1 million] global DALYs), smoking (148·6 million [134·2 million to 163·1 million]), high fasting plasma glucose (143·1 million [125·1 million to 163·5 million]), high BMI (120·1 million [83·8 million to 158·4 million]), childhood undernutrition (113·3 million [103·9 million to 123·4 million]), ambient particulate matter (103·1 million [90·8 million to 115·1 million]), high total cholesterol (88·7 million [74·6 million to 105·7 million]), household air pollution (85·6 million [66·7 million to 106·1 million]), alcohol use (85·0 million [77·2 million to 93·0 million]), and diets high in sodium (83·0 million [49·3 million to 127·5 million]). From 1990 to 2015, attributable DALYs declined for micronutrient deficiencies, childhood undernutrition, unsafe sanitation and water, and household air pollution; reductions in risk-deleted DALY rates rather than reductions in exposure drove these declines. Rising exposure contributed to notable increases in attributable DALYs from high BMI, high fasting plasma glucose, occupational carcinogens, and drug use. Environmental risks and childhood undernutrition declined steadily with SDI; low physical activity, high BMI, and high fasting plasma glucose increased with SDI. In 119 countries, metabolic risks, such as high BMI and fasting plasma glucose, contributed the most attributable DALYs in 2015. Regionally, smoking still ranked among the leading five risk factors for attributable DALYs in 109 countries; childhood underweight and unsafe sex remained primary drivers of early death and disability in much of sub-Saharan Africa. Interpretation Declines in some key environmental risks have contributed to declines in critical infectious diseases. Some risks appear to be invariant to SDI. Increasing risks, including high BMI, high fasting plasma glucose, drug use, and some occupational exposures, contribute to rising burden from some conditions, but also provide opportunities for intervention. Some highly preventable risks, such as smoking, remain major causes of attributable DALYs, even as exposure is declining. Public policy makers need to pay attention to the risks that are increasingly major contributors to global burden. Funding Bill & Melinda Gates Foundation

SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal

Genomic surveillance of SARS-CoV-2 in Portugal was rapidly implemented by the National Institute of Health in the early stages of the COVID-19 epidemic, in collaboration with more than 50 laboratories distributed nationwide. Methods By applying recent phylodynamic models that allow integration of individual-based travel history, we reconstructed and characterized the spatio-temporal dynamics of SARSCoV-2 introductions and early dissemination in Portugal. Results We detected at least 277 independent SARS-CoV-2 introductions, mostly from European countries (namely the United Kingdom, Spain, France, Italy, and Switzerland), which were consistent with the countries with the highest connectivity with Portugal. Although most introductions were estimated to have occurred during early March 2020, it is likely that SARS-CoV-2 was silently circulating in Portugal throughout February, before the first cases were confirmed. Conclusions Here we conclude that the earlier implementation of measures could have minimized the number of introductions and subsequent virus expansion in Portugal. This study lays the foundation for genomic epidemiology of SARS-CoV-2 in Portugal, and highlights the need for systematic and geographically-representative genomic surveillance.We gratefully acknowledge to Sara Hill and Nuno Faria (University of Oxford) and Joshua Quick and Nick Loman (University of Birmingham) for kindly providing us with the initial sets of Artic Network primers for NGS; Rafael Mamede (MRamirez team, IMM, Lisbon) for developing and sharing a bioinformatics script for sequence curation (https://github.com/rfm-targa/BioinfUtils); Philippe Lemey (KU Leuven) for providing guidance on the implementation of the phylodynamic models; Joshua L. Cherry (National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health) for providing guidance with the subsampling strategies; and all authors, originating and submitting laboratories who have contributed genome data on GISAID (https://www.gisaid.org/) on which part of this research is based. The opinions expressed in this article are those of the authors and do not reflect the view of the National Institutes of Health, the Department of Health and Human Services, or the United States government. This study is co-funded by Fundação para a Ciência e Tecnologia and Agência de Investigação Clínica e Inovação Biomédica (234_596874175) on behalf of the Research 4 COVID-19 call. Some infrastructural resources used in this study come from the GenomePT project (POCI-01-0145-FEDER-022184), supported by COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation (POCI), Lisboa Portugal Regional Operational Programme (Lisboa2020), Algarve Portugal Regional Operational Programme (CRESC Algarve2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), and by Fundação para a Ciência e a Tecnologia (FCT).info:eu-repo/semantics/publishedVersio